Abstract

BUBBLE LIPOSOME: A MODERN THERANOSTIC APPROACH OF NEW DRUG DELIVERY

Arpan Mahanty, Yanan Li, Yinglan Yu, Parikshit Banerjee, Birendra Prasad Chaurasiya, Jiasheng Tu* and Chunmeng Sun*

ABSTRACT

Liposome-based drug and gene delivery systems have potential roles in a variety of therapeutic applications. Recently, liposomes have been used to entrap bioactive gases and/or drugs for ultrasound-controlled drug release with enhanced drug delivery. Echogenic liposomes have been produced by different preparation methods, including the modern development of delivery. Presently, significant in vivo applications of liposomal ultrasound-based drug and gene delivery are being made in cardiac disease, stroke and tumor therapy. Translation of these vehicles into the clinic will require a better understanding of improved physical properties to avoid rapid clearance, as well as of possible side effects, including those of the ultrasound. The aim of this review is to provide orientation for new researchers in the area of bubble liposomes for the delivery of therapeutic bioactive gases, drugs and genetic materials.

Keywords: Bubble liposome, Gas filled Liposome, Gas generating liposome, Liposome preparation Technique.