Abstract

ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITIES OF ETHANOLIC LEAF EXTRACT OF CROTON BONPLANDIANUM BAILL IN STREPTOZOTOCIN INDUCED DIABETIC RATS

*Bimala Tripathy, S. Satyanarayana, K. Abedulla Khan, Bishnu Charana and K. Raja

ABSTRACT

Sugar diabetes (Diabetes mellitus) is an unhumorous physical complication with incessantly growing rates of prevalence and loss of life. Diabetes mellitus is a group of metabolic disorder in which there are high blood sugar levels over a prolonged period due to insufficient insulin and insulin resistance, or both, leading to disturbances of carbohydrates, fat and proteins metabolism. The eminent objective of this work was to find out the anti-diabetic activity of Croton bonplandianum Baill in Streptozotocin induced diabetes on Wistar rats. The method of anti-diabetic effect of ethanol leaf extract of Croton bonplandianum Baill (50,100,200mg/kg body weight) were administered orally in diabetic rats. After the oral administration of such ethanol leaf extract the blood glucose levels were monitored at specific intervals. In consequence it was observe that extract was significantly reduced blood glucose level. Simultaneously the action of the extract on diabetes induced hyperlipidemia was examined where it notably decreased the elevated total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) level while increased the high density lipoprotein (HDL). Glibenclamide was used as a standard drug at a dose of 4 mg/kg. The conclusion of the experimental reading exhibited that the ethanolic extract has significantly shows anti-diabetic activity in Streptozotocin-induced rats compared to the standard drug.

Keywords: Antidiabetic Croton bonplandianum Baill, Glibenclamide, Streptozotocin.