Abstract

FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF GABAPENTIN

*Syed Suhaib Ahmed, K. Radha, V. Sunitha, V. Sowmya, S.K. Irfan Khan, K. Rajeshwar Dutt

ABSTRACT

Oral administration is one of the most convenient forms for the intake of drug due to ease of administration, painless , versality and paramount patient compliance. The demand of fast disintegrating tablets has been growing, during the last decades especially for geriatric and pediatric patients due to dysphasia. So the new drug delivery known as orally disintegrating tablets came to existence. An attempt has been made to prepare fast dissolving tablets of Gabapentin using super disintegrants like cros carmellose sodium, crospovidone, PVP K-30. All the formulations were evaluated for post-compression parameters like hardness, friability, dug content uniformity, dissolution test and disintegration test. The max of gabapentin was scanned for 0.1N HCL buffer. The maximum absorbance 221 nm was done. Finally F3 formulation is best formulation based on drug release characteristics.

Keywords: Gabapentin, cros povidine, cros carmellose sodium, PVP K-30, Mannitol.