Abstract

RECENT ADVANCE IN DEVELOPMENT OF 3-METHYL-4-ARYLMETHYLENE ISOXAZOLE-5(4H)-ONES AND 6-AMINO-1,4-DIHYDROPYRANO[2,3-C]-PYRAZOLE-5-CARBONITRILES: SYNTHETIC APPLICATIONS AND PATHWAYS

Rajesh H. Vekariya, Neelam P. Prajapati, Kinjal D. Patel, Mayur K. Vekariya, Dhaval B. Patel and Hitesh D. Patel*

ABSTRACT

3-methyl-4-arylmethylene isoxazole-5(4H)-ones and 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitriles are utilized as a building blocks in synthetic organic chemistry, which serves as growing scaffolds for the development of various biologically important heterocyclic compounds. This review covers recent synthetic advances in the preparation of heterocyclic compounds utilizing various 3-methyl-4-arylmethylene isoxazole-5(4H)-ones and 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitriles via one-pot multicomponent reactions.

Keywords: Isoxazole-5(4H)-ones, pyrano[2,3-c]-pyrazoles, catalysis, organocatalysts, heterocyclic synthesis, multicomponent reactions, one-pot reaction.