Abstract

EFFECT OF NUTMEG (Myristica fragrans) ON OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC IN WISTAR ALBINO RATS

*Eweje Adebimpe Oyindamola, Ajayi Olubunmi Bolanle and Oseni Olatunde Abass

ABSTRACT

Plants contain many important and potential therapeutic agents for treating several diseases of man. In this study, we investigate and compare the hypoglycemic with lipid profile evaluations of nutmeg (Myristica fragrans) seed on Alloxan-induced diabetic albino rats with the aim of alleviating oxidative stress. Twenty matured male wistar albino rats were acclimatized for one week. The animals were grouped into 5 groups (1, 2, 3, 4 and 4) containing four rats each. Group 1(normal) was fed with rat pellets, Group 2 (negative control) was fed with normal rat feed, Group 3 animals was treated with 0.5ml of 30% aqueous extract of nutmeg (myristical fragrans), while group 4 and 5 animals were treated with 5% and 10% formulated feed respectively. Blood samples were collected for glucose, total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and tryglyceride determination. The result of this work revealed that 30% aqueous extract, 5% and 10% supplemented nutmeg (Myristical fragrance) caused increased weight and high density lipoprotein (HDL) concentration and decrease in blood glucose, low density lipoprotein (LDL), triglyceride and total cholesterol. Thus, from this study we conclude that nutmeg (Myristical fragrance) diet exhibited significant anti-hyperglycemic in alloxan-induced diabetic rats.

Keywords: Therapeutic agent, Anti-diabetic activity, Myristical fragrans, Intra-peritoneally.