Abstract

PREPARATION, CHARACTERIZATION OF ACECLOFENAC- GELATIN NANOCOMPOSITES, FOR SOLUBILITY, DISSOLUTION RATE AND ANTI INFLAMMATORY STUDY

Preethi S.*, Dr. Ramesh Babu N. G., Karthikeyan S. and Dr. Ragunathan R.

ABSTRACT

The present study focuses on the biosynthesis and characterization of aceclofenac-gelatin nanocomposites. Four different concentrates of aceclofenac-gelatin nanocomposites were synthesized and characterized by using UV-Visible absorption spectrophotometer, FTIR (Fourier’s Transform Infrared spectrophotometer) and FESEM (Field Emission Scanning Electron Microscopy). Among the four altered concentrations, 1.0 g of gelatin concentration showed the maximum efficiency of 53.574%. The size of the nanocomposite was found to be 4.3 mm. The anti-inflammatory study was carried out on the synthesized nanocomposites. The impact of drug release, effect of drug release of aceclofenac-gelatin nanocomposite in phosphate buffer was studied by dialysis and microsphere methods. Anti-inflammatory test was carried out for the estimation of saturation solubility of the gelatin coated drug. The antimicrobial activity of the nanocomposites were studied against gram negative bacteria and the results showed 50% reduced growth.

Keywords: FTIR, FESEM, Anti-inflammatory study, Antimicrobial activity, Aceclofenac-gelatin nanocomposites, dialysis.