Abstract

EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF CRINUM LATIFOLIUM LEAVES ON ALBINO MICE

K. Kaushik*, A. Upadhyay, L. Khurana, Azharuddin, S. S. Saurabh, J. Dwivedi, G. Jeyabalan

ABSTRACT

In present study, the dried leaves of Crinum latifolium were selected for preliminary phytochemical investigation and pharmacological evaluation for its analgesic and anti-inflammatory activity. The dried leaves were subjected to extraction with alcoholic/aqueous solvents. Then extract were subjected to qualitative chemical test for identification of phytoconstituents. As a model of chronic inflammation, cotton pellet induced granuloma in rats was utilized in the present study. As a model of acute inflammation, acetic acid induced writhing test and formalin test were utilized in the present study. In conclusion, the results of the present study demonstrated that aqueous extract of Crinum latifoliumin produced dose related acute anti-inflammatory activity (Carrageenan, dextran, histamine and formalin), chronic anti-inflammatory activity (Cotton pellet) and analgesic activity (Acetic acid and formalin). These studies have shown that the aqueous extract of Crinum latifoliumin contains some active ingredients with the potential of being good anti-inflammatory and analgesic agents.

Keywords: Phytoconstituents, chronic inflammation, acute inflammation.