Abstract

PREPARATION OF FAST DISSOLVING TABLETS USING NATURAL SUPER DISINTEGRANT

K. Srinivasarao*, B. Sai Adithya, K. Sai Lakshmi Jyothrmai,
M.D. Gulshan, N. Rama Rao

ABSTRACT

The main objective of preparing of fast dissolving tablets of glipizide to dissolve rapidly to show great bio availability can be done by using natural superdistintegrant in case of synthetic superdistintegrant. The formulation was prepared by direct compression using natural superdistintegrant i.e. isolated mucilage of Plantago ovata. Initially dissolution and disintegration test were carried to know the disintegration and dissolution of drug in stomach pH. The absorbance of drug by using U.V spectroscopy to know the absorbance of drug. Thus superdistintegrant along with their role in tablet disintegration and drug release, which are being used in the formulation to provide the safer, effective drug delivery with patient compliance.

Keywords: fast dissolving tablet, isolate mucilage of Plantago ovate.