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IDENTIFICATION OF COST EFFECTIVE DRUG THROUGH IN-SILICO APPROACH OF CATHARANTHUS ROSEUS PLANT LIGAND-RECEPTOR DOCKING FOR TYPE 2 DIABETES NIDDM
*Priyanka Tolambiya and Sujata Mathur
ABSTRACT
Objective:- Diabetes type2 is common disease found in every age-segment of human beings. This study was proposed to design cost effective drug through herbal medicinal plant Catharanthus roseus and its parts, directly or indirectly being used for diabetes treatment. Methodology:- GCMS is conducted on alcoholic stem extraction to identify the different alkaloids substances. The chemical structure of these alkaloids was identified through pubchem database. PTB1B is a novel target for type 2 diabetes and its 3D structure designed by target sequence. The blast of target sequence was performed with PDB to get template 1NL9 which is 100% identical with target sequence. As a Keywords: PTP1B, 1NL9, Docking, Catharanthus roseus. Type 2 Diabetes. [Download Article] [Download Certifiate] |