Abstract

FORMULATION AND EVALUATION OF EZETIMIBE NANOSUSPENSIONS BY USING PRECIPITATION METHOD

Goutham Kuppili*, Prasanna Kumar Desu and Pasam Venkateswara Rao

ABSTRACT

In the present study, an attempt was made to prepare Nanosuspension of Ezetimibe is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Nanosuspension containing the drug were prepared by precipitation method using combinations of polymers such as PVP K-25, Sodium lauryl sulphate (SLS), urea, poloxamer (188), and methanol. Estimation of Ezetimibe was carried out spectrophotometrically at 232nm. The Oral Nanosuspension were evaluated for various physical and biological parameters, drug content uniformity, particle size analysis, zeta potential, in-vitro drug release, short-term stability, drug- excipient interactions (FTIR). IR spectroscopic studies indicated that there are no drug-excipient interactions. The formulations F1 to F9 (containing PVP K-25, Urea, SLS, Poloxamer (188), and Methanol) used different ratio were found to be promising, of that formulation F9 containing Urea showed 99.43% release at the end of 25min & it follows zero order drug release kinetics. These formulations have displayed good Nanosuspension strength.

Keywords: Ezetimibe, Nanosuspension, PVP K-25, SLS, poloxamer (188), Urea and Methanol.