Abstract

EVALUATION OF ANTIULCER ACTIVITY OF MUSA PARADISIACA L. (PEUDOSTEM) IN PYLORUS LIGATED AND ETHANOL INDUCED WISTAR ALBINO RATS.

Abirami J.* and Brindha P.**

ABSTRACT

The Antiulcer activity of aqueous pseudostem of Musa paradisiaca L was investigated on pylorus ligation model and Ethanol induced ulcer model in wistar rats. In both models the common parameters determined was ulcer index, ulcer score, volume of gastric juice, Antioxidant parameters such as glutathione peroxidase, superoxide dismutase, lipid peroxides, In Ethanol induced model, mucus was analysed. In Ethanol induced model, mucus levels were increased in plant treated animals compared to control. The aqueous pseudostem juice of Musa paradisiaca L. of dosage 100, 200, and 300 mg/kg produced significant inhibition of gastric lesion induced by pylorus ligation and Ethanol induced ulcers. The aqueous pseudostem juice of Musa paradisiaca L. of dosage 100, 200, and 300 mg/kg showed significant reduction in gastric volume, free acidity, total acidity, and ulcer index as compared to control. The study indicates that aqueous pseudostems of Musa paradisiaca L. have potential antiulcer activity in both models. These results indicated that Musa paradisiaca L. (Pseudostem) displayed an antiulcerogenic effect due to its cytoprotective activity. Besides antioxidant potential of plant extract scavenged the free radicals produced by Ethanol induction, pylorus ligation and healed the ulcers.

Keywords: Musa paradisiaca L (Pseudostem), Ulcer index, Antioxidant.