Abstract

AN OVERVIEW ON NOVEL TRENDS IN ORALLY MOUTH DISSOLVING TABLET

Muthadi Radhika Reddy*, Ayesha Sulthana, A. Jayanthi Reddy and P. Kranthi Kumar

ABSTRACT

Novel drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and bio-chemical parameters pertinent to their performance. Fast dissolving tablet (FDT) is one such type of an innovative and unique drug delivery system which is swiftly gaining much attention in the research field of rapid dissolving technology. The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. One such problem can be solved in the novel drug delivery system by formulating “mouth dissolving tablets” (MDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. Despite tremendous advancements in drug delivery, the oral route remains the perfect route for the administration of therapeutic agents because the low cost of therapy and ease of administration lead to high levels of patient compliance. Patient convenience and compliance oriented research have resulted in bringing out safer and newer drug delivery systems. Recently, fast dissolving drug delivery systems have started gaining popularity and acceptance, as one such example, with increased consumer choice, for the reason of rapid disintegration or dissolution and self-administration even without water or chewing and provides a quick onset of action. The aim of the review article is to give an overview on potential benefits offered by FDTs as an oral drug delivery system for various kinds of patients suffering from different diseases and disabilities. Desired characteristics and challenges for developing fast disintegrating drug delivery systems, quality control tests, various techniques used in the preparation of fast disintegrating drug delivery systems like lyophilisation technologies, tablet molding method, sublimation techniques, spray drying techniques, mass extrusion technology, use of superdisintegrants and also reviews the patented technologies for fast disintegrating dosage forms and future prospects.

Keywords: Fast dispersing tablet, patented technology, superdisintigrants, improved bioavailability, novel dosage forms, mouth dissolving tablet.