FLOATING MICROSPHERES: AN OVERVIEW
Sumita Singh* and Kunal Arora
ABSTRACT
This review reveals the importance, efficiency and efficacy of floating
drug delivery systems (FDDS). The principal and mechanism of
floatation to achieve gastric retention is being discussed in this study.
The recent developments of FDDS including the physiological and
formulation variables affecting gastric retention, approaches to design
single-unit and multiple-unit floating systems, and their classification
and formulation aspects are covered in detail. This review also
summarizes the in vitro techniques, in vivo studies to assess the
performance and application of floating systems, and applications of
these systems. These systems are helpful to several problems
encountered during the development of a pharmaceutical dosage form.
Keywords: Floating drug delivery, Microsphere, Gastric retention, Intragastric.
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