Abstract

SYNTHESIS AND IN VITRO BIOLOGICAL EVALUATION OF THIAZOLO DERIVATIVES LINKED TO INDOLE NUCLEUS.

Ramachandra A.*, Manjunath Y., Kirankumar N. M. and Anuradha K.

ABSTRACT

A series of novel indole derivatives 1-((2-substituted phenyl-1H-indol- 3-yl)methylene)-2-(substituted thiazol-2-yl)hydrazide (7a-h), 3-(4- substituted phenyl thiazol-2-ylamino)-2-(2-substituted phenyl-1Hindol- 3-yl)thiazolidin-4-one (8a-h) and 1-(4-substituted phenyl thiazol- 2-ylamino)-3-chloro-4-(2-substitutedphenyl-1H-indol-3-yl)azetidin- 2one (9a-h) were prepared. The newly synthesized compounds have been characterized by their IR, 1H NMR and Mass spectral studies. And were screened for their antioxidant and antimicrobial activity. Some of the compounds were found to be equipotent or potent than commercial drugs as evident from results.

Keywords: Indole, thiazole, azitidine, antioxidant, antimicrobial activity.