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PREPARATION AND IN-VITRO EVALUATION OF MOUTH DISSOLVING TABLETS OF VOGLIBOSE 2015-2016
Dr. Shivanand Kalyanappa*, Dr. Dana Bayemaninezhad, Dr. Anirbandeep Bose, Dr. Ali Khodayarlou and Dr. Divakar Goli
ABSTRACT
This study was aimed at development of voglibose mouth dissolving tablets which can disintegrate or dissolve rapidly once placed in the oral cavity. Voglibose is α-glycosidase inhibitor, drug which is used in a treatment of type 2 diabetes mellitus. The tablets were prepared with different superdisintegrant like croscarmellose sodium, sodium starch glycolate and methyl cellulose at different concentrations. The blend was evaluated for angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio, and Infrared studies. The tablets were evaluated for thickness, hardness, friability, weight variation, content uniformity test, in-vitro disintegration time, wetting time, and in-vitro dissolution studies. The most satisfactory formulation F6 showed minimum disintegration time of 31 sec and release maximum amount of drug in shortest duration of time in 10 min. It was found to be stable during short term stability studies conducted for 2 months. Kinetic studies revealed zero order model. Keywords: Mouth Dissolving Tablets; Superdisintegrants; Voglibose; Type 2 diabetes mellitus. [Download Article] [Download Certifiate] |