Abstract

EFFECT OF ANTI-INFLAMMATORY ACTIVITY OF HELLENIA SPECIOSA (L.) AND COSTUS PICTUS (L.)

Ramya R.* and Dhamotharan R.

ABSTRACT

The inflammatory response is a dynamic continuum, initiated by the host in response to tissue injury or infection, induces the arachidonic acid. The most abundant polyunsaturated fatty acid in the phospholipid bilayer of cell membranes which may be metabolized by two different pathways to form eicosanoid. Estimation of these eicosanoids levels by invitro and invivo proves the effectiveness of the compound to possess anti-inflammatory activity. With this hypothesis, Hellenia speciosa (L.) and Costus pictus (L.) were tested for invitro inhibition of albumin denaturation and membrane (human red blood cells) stabilization test. Further invivo LPS induced sepsis model estimated the amount of eicanosoid - TNF alpha. These experiments proved that among the plants, Hellenia speciosa is having potent anti-inflammatory than Costus pictus (L.)

Keywords: Anti-inflammtory, Hellenia speciosa (L.), Costus pictus (L.), TNF alpha, Inhibition of albumin denaturation, membrane stabilization, sepsis.