Abstract

SYNTHESIS OF NOVEL SUBSTITUTED 2H-THIAZOLO [3,2-a] PYRIMIDINES USING WATER AS GREEN SOLVENT AND THEIR ANTIMICROBIAL EVALUATION

Vipul B. Audichya, Mahesh M. Savant and Yogesh T. Naliapara*

ABSTRACT

A novel series of N,5-bis(4-fluorophenyl)-3,5-dihydro-7-isopropyl-2H-thiazolo[3,2-a]pyrimidine -6-carboxamide has been prepared by reaction of N,4-bis(4-fluorophenyl)-1,2,3,4-tetrahydro-6-isopropyl-2-thioxopyrimidine-5-carboxamide with dibromoethane using basic catalysts TEA/ K2CO3, in the presence of TBAB/TEAB in water. We found water as an efficient and green solvent for the synthesis of novel thiazolo [3,2-a] pyrimidine scaffolds in good yields for biological interest. Among all compounds, 8c, 8g, 8i, 8l and 8o shows good antimicrobial activity against bacterial strain compare to ciprofloxacin.

Keywords: Thiazolo[3,2-a]pyrimidine, Pyrimidine, Alkylation Antimicrobial evaluation.