Abstract

TO STUDY THE STABILITY CONSTANT OF SUBSTITUTED THIOCARBAMIDOPHENOL BY JOB’S VARIATION METHOD.

S.O. Mohod* and D.T. Tayade

ABSTRACT

Stability constant is an effective parameter in pharmacodynamics and pharmacokinetic study of molecules. The medicinal properties of any molecule are checked after synthetic process for that various physical methodologies are used. The stability constant of complexes of metal ions Cu(II), Co(II), Cd(II) and Ni(II) with 2-phenyl thiocarbamdophenol (L1) and 2-tolyl thiocarbamidophenol (L4) were examined in mixed solvent media by Job’s variation method. The conditional stability constant (log K) which obtained from the measured absorbance. The logK values were used to study the confirmation of complex formation.

Keywords: Substituted thiocarbamidophenols, stability constant, Spectrophotometry.