Abstract

TRANSDERMAL DRUG DELIVERY SYSTEMS FOR NON STEROIDAL ANTI-INFLAMMATORY DRUG DRUGS PREPARED BY ORGANOGEL-A REVIEW

R.M. Jagtap*, S.S. Patil P.J. Gaikwad and N.K. Mujawar

ABSTRACT

A simple working definition of the term ―gel‖ is a soft, solid or solid-like material, which contains both solid and liquid components, where the solid component (the gelator) is present as a mesh/network of aggregates, which immobilizes the liquid componentInflammation is one of the largest deaths causing disease for the mankind. Since it is aacute as well as chronic disease it necessitates long term treatment. The disadvantages of non steroidal anti-inflammatory drugs, such as more frequent of administration, extensive first pass metabolism and variable bioavailability, make it is an ideal candidate for transdermal drug delivery systems. This article is dedicated to the review of organogel of non steroidal anti-inflammatory drugs, transdermal in the perspective of enhancing the bioavailibity as well as in improving the patient compliance. The various of non steroidal anti-inflammatory drugs, considered in the review includes piroxicam, acetaminophen, rnoxicam, ketoprofen, flurbiprofen, ketorolac triethanolamine, ibuprofen, diclofenac sodium, and aceclofenac. And how the various ingredient and method of preparation affect on drug release. Give useful information regarding how organogel act as a candidate for both hydrophilic and lipophilic drugs.

Keywords: Non steroidal anti-inflammatory drugs. drugs, Organogel, Organogelator, Transdermal drug delivery systems.