DERMAL DELIVERY OF GLUCOSAMINE SULPHATE: FORMULATION, CHARACTERIZATION AND PERFORMANCE EVALUATION
Arvind Sharma* , Sandeep Arora
ABSTRACT
Background:-Oral glucosamine sulfate (GS ) is marketed as a
treatment of osteoarthritis. Since drug has short half life of 1 hr, dosage
regimen of (GS ) is 500mg TDS. In bid to reduce the frequency of
dosing and to improve patient compliance, a sustained formulation of
glucosamine (GS ) is desirable. The purpose of this research was to
study whether the bioavailability of Glucosamine could be improved
by administering drug entrapped in fatty acid vesicles (FAV) topically
Methods :- FAV were developed using rota evaporater followed by
ultrasonication. Particle size and zeta potential were measured by
photon correlation spectroscopy. Preformulation studies of different
FAV formulations were carried out along with in-vivo studies in rats.
Results:- Stable FAV formulation having a mean size range of 100 to
150 nm and a zeta potential range of –20 to –23 mV were developed.
More than 60% of the drug was entrapped in the FAV. In vitro
performance studies showed sustained release and stability of FAV. The muscle to plasma
concentration ratio for niosomal gel formulation was six and for carbopol gel it was one Plain
gel showed insignificant improvement whereas drug loaded FAV showed 25% remission in
inflammation after the 15th day and 51% at the end of study (28th day)Conclusion:- Based
upon these results it can be serve as ideal carrier as alternate for topical delivery of Antiarthritic
drug.
Keywords: Anti-arthritic drug, oleic acid vesicle.
[Download Article]
[Download Certifiate]