Abstract

FORMULATION AND EVALUATION OF TOPICAL DELIVERY OF ANTIFUNGAL DRUG BIFONAZOLE USING MICROEMULSIONBASED GEL FORMULATIONS

Manisha Karpe*, Vilasrao Kadam, Nikhil Mali, Vruti Patel, Namrata Jadhav

ABSTRACT

The objective of the present investigation was to develop and evaluate microemulsion based gel for topical delivery of Bifonazole. The solubility of Bifonazole in various oils, surfactants and co-surfactants were checked to identify components of the microemulsion. The pseudo-ternary phase diagrams were plotted to identify the area of microemulsion existence. Xantham gum was selected for the formulation of microemulsion based gel. The prepared formulations of Bifonazole Microemulsion based gel was evaluated by checking its pH, spreadability, rheological studies and in-vitro drug release studies. The Bifonazole Microemulsion based gel showed good in vitro drug release and anti-fungal activity. The Bifonazole Microemulsion based gel has potential be successfully used for the topical treatment of dermatomycoses.

Keywords: Microemulsion, Bifonazole, pseudo-ternary phase diagram, dermatomycoses.