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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF HEXAMETHYLENETETRAMINE COPPER (II) COMPLEX
Berhanu Degagsa, Gezahegn Faye*, Nester Fernandez
ABSTRACT The complex, [Cu(C6H12N4)3(H2O)3]SO4, has been synthesized in a mixed solvent of water and ethanol. It has been characterized by Infrared and Electronic Spectra, Magnetic Susceptibility, Melting Point and Conductivity measurement. Quantitatively, Copper ion, Sulphate ion and HMTA in the complex were determined with the help of Flame Atomic Absorption Spectroscopy, Gravimetric and Volumetric Analysis respectively. The study results suggested distorted octahedral complex in which the central metal ion, Cu (II), is bonded to three water and three HMTA ligands. The ligand, HMTA, is active against Pseudomonas aeruginosa and Salmonella typhi while it is inactive against Staphylococcus aureus and Escherichia coli. But, the complex is active against all the four tested bacteria species. Specially, the complex showed greater activity than the reference antibiotic, gentamycin, against Staphylococcus aureus and Salmonella typhi. Keywords: [Download Article] [Download Certifiate] |