Abstract

DEVELOPMENT AND EVALUATION OF CYCLODEXTRIN BASED NANOSPONGES FOR BIOAVAILABILITY ENHANCEMENT OF POORLY BIOAVAILABLE DRUG

Singh Alka*

ABSTRACT

Cyclodextrin nanosponges are solid, porous, bio-compatible, nano-particulate three dimensional structures which form complexes with different types of lipophilic or hydrophilic drug molecules and have been used as drug carrier for different drugs. In this present work, new cyclodextrin-based nanosponges were purposely designed as novel Ganciclovir carriers and were prepared by condensation polymerization method. Ganciclovir is weak base and completely solubilize at pH 7.4. Due to pH dependent solubility nature, the oral bioavailability of ganciclovir is very low i.e. 6-7%. Nanosponges have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamics properties of various types of drug molecules. Thus the major aim of present study was to enhance the oral bioavailability of ganciclovir via drug delivery through beta-cyclodextrin nanosponges which subsequently reduce the dose and dose related side effects. Cyclodextrin nanosponges (CDNS) were synthesized by using beta-cyclodextrin and carbonyldiimidazole which act as crosslinking agent. Drug loading was done by solvent evaporation method. Prepared CDNS were characterized by infrared spectroscopy (IR), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The particle size of 229.3 nm was observed for CDNS. The entrapment efficiency of 57.02 ± 5.59% was observed. Thus CDNS were successfully prepared for improvement of drug delivery.

Keywords: Beta-cyclodextrin, cyclodextrin nanosponges, carbonyldiimidazole, ganciclovir, dimethyl formamide.