Abstract

PROTECTVE ROLE OF LIV.52 AGAINST RADIATION AND CADMIUM INDUCED HAEMOGLOBIN (HB) CHANGES IN THE SWISS ALBINO MICE

Sharma Ramakant* and Purohit Rajendra

ABSTRACT

The present study was aimed to evaluate protective efficacy of a herbal drug Liv.52 against radiation and cadmium induced Haematological changes in the Swiss albino mice. The animals treated with gamma radiation and/or cadmium chloride with and without Liv.52 were sacrificed by cervical dislocation at post treatment intervals of 1, 2, 4,7,14 and 28 days. The values of Hb found to increase up to day-14 in non drug treated groups and day-7 in drug treated groups. Thereafter a decrease in the value was observed without reaching to the normal. When the animals were treated with radiation and cadmium chloride simultaneously, synergistic effects were observed. In all drug treated groups recovery started earlier than that in non drug treated groups. The Liv.52 treated animals exhibited less severe damage and early recovery as compared to non drug treated groups. Thus, it appears that Liv.52 is potent enough to check Haematological change in the Swiss albino mice.

Keywords: Radiation, Cadmium, Liv52, Haematological change, Hb, Mice.