Abstract

METHANOLIC EXTRACT OF SPILANTHES CALVA IMPROVES GLIBENCLAMIDE-INDUCED GLUCOSE TOLERANCE

Mohammad Mahbubur Rahman Bhuiyan, Ummey Jannatun Nahar and Mohammed Rahmatullah*

ABSTRACT

Background. Spilanthes calva is an herbaceous plant found in the wild in Bangladesh. Since the plant’s aerial parts have been previously reported for antihyperglycemic effects, it was of interest to determine whether the aerial parts can improve the oral glucose tolerance in mice induced by an antihyperglycemic drug, glibenclamide. Methods. Antihyperglycemic activity was determined through oral glucose tolerance tests (OGTT) in mice. Results. Administration of methanol extract of aerial parts of the plant (MESC) to glucose-loaded mice at a dose of 400 mg per kg body weight led to reduction in blood glucose levels by 34.8%. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg reduced blood glucose level by 42.6%. Administration of 10 mg glibenclamide per kg with, respectively, 100, 200, and 400 mg per kg MESC, led to reductions in blood glucose levels by 42.9, 49.1, and 52.7%. Conclusion. Methanol extract of aerial parts of the plant can improve oral glucose tolerance in mice induced by an antihyperglycemic drug, glibenclamide.

Keywords: Antihyperglycemic, Spilanthes calva, glibenclamide, OGTT.