Abstract

POTENTIAL USE OF MUCIN AS BIOMARKER FOR THE DIAGNOSIS OF BREAST CANCER

Abdelfattah M. Attallah*, Mohamed El-Far, Mohamed M. Omran, Mohamed S. Elbendary, Karim S. Salama and Ibrahim El-Dosoky

ABSTRACT

Background and Aim: Breast cancer is considered the leading cause of cancer death among females in developing countries. Tumor markers are biochemical indicators for the presence of tumor. Aim of study to identify, quantity and evaluate of mucin-1 for diagnosis breast cancer. Methods: Sodium dodecyl sulfate-polyacrylamide gel electrophoresis, western blotting and enzyme linked immunosorbent assay (ELISA) were used for identifying mucin-1 in sera of women with breast cancer (n= 88) and healthy women (n= 32). Results: MUC1 was identified at 130 kDa. The mean level of serum mucin-1 in women with breast cancer was higher than (5.60 ± 0.68 μg/ml) in the healthy women (1.32 ± 0.16 μg/ml) with extremely high significant difference (p < 0.0001). There was significant correlation between age and Mucin-1 in women with breast cancer (r = 0.40; p

Keywords: Mucin, Breast Cancer, Blood markers, Diagnosis.