Abstract

FORMULATION AND EVALUATION OF POTENTIAL ANTIDIABETIC DRUG FROM MOMORDICA CHARANITA

Shiva G., Rupa V.* and Dr. Manjula Talluri

ABSTRACT

The aim of the present work is to formulate a stable formulation of sustained release tablets of Momordica charanita. Momordica charanita is a potent anti-diabetes drug used in the treatment of Diabetes Mellitus. The formulation was developed using direct compression technique. HPMC 50cps, Eudragit L100, Ethyl cellulose are the polymers used in the formulation. FT-IR (infrared spectroscopy) studies were performed to confirm the compatibility of the drug and excipients. Total 12 formulations (S1 to S12) were prepared and evaluated. The in-vitro release of the formulations was carried out in 0.1N HCL for 2hrs and in phosphate buffer of pH6.8 for 10hrs. Among all the formulations S10 was selected as best formulation because it show better percentage drug release of 34.91±0.23% in 0.1N HCL after 2hrs and 86.64±0.12% at the end of 10hrs in phosphate buffer of pH6.8. The release kinetics models were analyzed using the zero order model, first order model, & Higuchi square root equation. The optimized formulation S10 followed the first order release kinetics. Formulation S10 containing HPMC50 cps, and Eudragit L 100 (2:1) was able to retard the drug release for upto 12 hrs with maximum drug release of 86.64%. Three months stability study was conducted which confirmed that the optimized formula is stable.

Keywords: Momordica charanita, Sustained release, Direct compression, HPMC50cps, Eudragit L100, EC, In-vitro drug release, Stability studies.