Abstract

SYNTHESIS OF N-SUBSTITUTED IMIDAZOLE DERIVATIVES AND EVALUATION FOR ITS ANTIMICROBIAL ACTVITIY

Prof. Swati Burungale* and Prof. R. N. Patil

ABSTRACT

A series of N-substituted imidazole derivatives was synthesized. Imidazole nucleus was reacted with ethylchloroacetate to form imidazole ester. Reaction of the imidazole ester with different amines yields the desired products (1-5). The compounds were characterized by IR and 1H-NMR. The synthesized compounds were evaluated for the antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger by determination of MIC (minimum inhibitory concentration) using tube dilution method. Compound (2) was found to be the most active antimicrobial compound amongst others in the series. An increasing public health problem is disease- causing microbes that have become resistant to antibiotic drug therapy. The current antimicrobial therapy is increasingly compromised by the emergence and spread of bacteria resistant to commonly used antimicrobial agents.[1]

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