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Abstract

ANTIDIABETIC EFFECT OF BRIDELIA RETUSA SPRENG. BARK ON ALLOXAN-INDUCED DIABETIC RATS

Suhas Suresh Awati*, Sujit Arun Desai, Dhanraj Raghunath Jadge, Sunil Sambhaji Karale

ABSTRACT

Objectives: To evaluate the antidiabetic activity of ethyl acetate and methanolic bark extracts of Bridelia retusa Spreng. on alloxan-induced diabetic rats. Method: Diabetes was induced by a single dose of alloxan (120 mg kg-1 i.p) monohydrate. The acute and chronic study included the measurement of blood glucose level at 0, 1, 3, 5, 7, 24 hr and on 15th day after administration of extracts. Glibenclamide was used as a standard (5mg kg-1 orally). Result: Ethyl acetate and methanolic extracts showed more significant (P

Keywords: Alloxan, Antidiabetic, Bridelia retusa Spreng, Insulin.


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