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A NEW COLORIMETRIC DEVELOPMENT AND VALIDATION OF VISIBLE METHOD FOR ESTIMATION OF NAPROXEN IN BULK FORMULATION
Ch. Sai Manoj* and VVS. Rajendra Prasad
ABSTRACT A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Naproxen in Bulk form. The method is based on the reaction of Naproxen with MBTH Reagent [3-Methyl-2-Benzothiazolinone Hydrazone] in the presence of ferric chloride giving greenish blue colour chromogen which shows maximum absorbance at 580nm against reagent blank. The Chromogen obeyed Beer’s law in the concentration range of 10-50 μg/ml for Naproxen. The results of the analysis have been validated statistically and recovery studies. Keywords: Naproxen, MBTH Reagent [3-Methyl-2-Benzothiazolinone Hydrazone], Ferric chloride, Visible Spectrophotometric. [Download Article] [Download Certifiate] |