Abstract

BIO-EVALUATION OF HAIR GROWTH POTENTIAL OF THUJA ORIENTALIS LEAVES EXTRACT

Sudhir K. Thukral*, Sumitra Singh and Surendra Kr. Sharma

ABSTRACT

Androgenetic alopecia is a reversible patterned hair loss resulting into progressively decline in visible scalp hair density. Although it is a non serious condition, it may be an underlying antecedent for psychological disorders especially anxiety and depression. Indian and Chinese traditional system of medicine claims a number of plant drugs for hair growth promotion in humans. Therefore biological evaluation was undertaken to access the effect of Thuja orientalis (Linn.) Franco on hair growth activity in androgenetic alopecia in mice and rabbit. Quantitative and Qualitative studies were carried out and during the course of treatment hair growth initiation and completion pattern wereobserved. Rabbits treated with topical solution 2.5% and 5% Petroleum ether and Chloroform extract produced very significant effect (P< 0.001) on the hair growth when compared to other groups. Both Petroleum ether extract and chloroform extract in concentration of 2.5% and 5% were found significant (P< 0.01) in increasing hair length of rabbit as compared to control. When tested for hair growth on testosterone treated mice, topical solution containing 2.5% & 5% concentration of petroleum ether extract and chloroform extract of test plant showed significant (P < 0.01) results. The quantitative study revealed that topical solutions containing 2.5% and 5% of petroleum ether extract and chloroform extract increases the number of hair follicles in anagen phase and showed significant results (P < 0.01). Hence present study reveals that there is emerge need to isolate phytopharmaceuticals possessing potential hair growth activity with no adverse effect.

Keywords: Androgenetic alopecia, Thuja orientalis, Hair Growth.