Abstract

CURRENT AND EMERGING THERAPIES FOR THE MANAGEMENT OF DIABETIC RETINOPATHY

*Prof. Manodhini Elakkiya

ABSTRACT

Diabetic Retinopathy (DR) is the major complication of Diabetes Mellitus (DM). DR is a majour cause of blindness in working age people. The pathogenesis behind vision loss is increased retinal angiogenesis and retinal vascular permeability. There are many pathways which are responsible for DR, such as polyol pathway, protein kinase C (PKC) activation, renin angiotensin-aldosterone system (RAAS), oxidative stress etc are discussed in this review for better understanding of pathophysiology. Current and emerging therapies for DR includes PKC inhibitors, anti-inflammatory agents, RAAS blockers, anti-vascular Endothelial growth factor (VEGF) agents, antioxidants and fibrates are also elaborated in this review for effective management of DR.

Keywords: Diabetic retinopathy, Pathogenesis, current therapies, emerging therapies, Ocular neovascularisation.