Abstract

NATEGLINIDE: A REVIEW OF SPECTROSCOPIC AND CHROMATOGRAPHIC METHOD

Hetal Patel* and Dr. Dilip G. Maheshwari

ABSTRACT

Nateglinide is an Oral antihyperglycemic agent used for the treatment of non-insulin dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for quality control and pharmacodynamics and pharmacokinetic studies as well as stability study. There are many analytical methods reported so far in the literature for the determination of Nateglinide in Biological samples and pharmaceutical formulations. This article comprises reviews of analytical methods like Spectrophotometric methods, chromatographic methods.

Keywords: Nateglinide, Spectrophotometry, HPLC