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CEFTIOFUR SODIUM INDUCED CHANGES IN SPERM CHARACTERISTICS, REPRODUCTIVE ORGANS’ HISTOPATHOLOGY AND OXIDATIVE STRESS IN ADULT MALE RATS
El-Sayed M.G.A., Kandiel M.M.M. and Dr Ebied D.D.I.A.*
ABSTRACT
This study was conducted to clarify the implications arising from the use of ceftiofur sodium, third generation of cephalosporins, on male reproductive organs, testosterone hormone and testicular oxidative stress markers. Adult male rats (200-250 g) were daily subcutaneously injected with ceftiofur sodium at a dose of 7.2 mg or 14.4 mg/kg b.wt. for seven or fourteen days and scarified at the first, thirty and sixty day after the last dose of administration. Ceftiofur was noticed to induce a significant decrease in the index weight of the reproductive organs (testes, epididymis, seminal vesicle and prostate gland). Nevertheless, seminal vesicle and prostate gland weights increased at the 1st day Keywords: Ceftiofur, Semen Evaluation, Testicular Oxidative Stress, Testosterone. [Download Article] [Download Certifiate] |