Abstract

ANTI-ULCEROGENIC POTENTIAL OF NATURAL AND SYNTHETIC POORA PARPAM AGAINST INDOMETHACIN INDUCED GASTRIC ULCER IN WISTAR RATS

N. Kabilan* and M. Murugesan

ABSTRACT

Peptic ulcer disease is a term used for both stomach and duodenal ulcer. In clinical practice, peptic ulcer disease is most commonly known as a gastrointestinal disease which is interlinked with the acute and chronic inflammation of the gastric and duodenal epithelium. According to an estimation of the WHO, almost 80% of people globally are treated by traditional medicine. Siddha system of medicine is considered to be one of the oldest rejuvenating therapies known to mankind since centuries back. Siddha formulations have consistently proven its efficacy particularly in the management of gastric ulcer disease. In the present study, anti-ulcer property of siddha formulations natural and synthetic Poora parpam was evaluated against Indomethacin induced gastric ulcer model in rats. The result obtained from the study clearly shows that treatment with Natural and Synthetic Poora parpam significantly reduced the ulcer lesion index at dose level of dose of 1.15 and 2.30mg / kg. Similarly rats treated with standard drug Ranitidine (100 mg / kg) showed higher level of reduction in ulcer index when compare to positive control group. Standard drug Ranitidine (100 mg / kg) treated group has shown the highest percentage 69.9 % inhibition of ulcer ,where as Natural Poora parpam exhibit 38.43 and 57.99% inhibition at the dose of 1.15 and 2.30 mg / kg respectively. Similarly rats treated with Synthetic Poora parpam exhibit 29.12 and 48.21% inhibition at the dose of 1.15 and 2.30mg / kg respectively. Further these findings were supported and confirmed by gross anatomical observation and histological examination. From the results of the present investigation it was concluded that formulation like Poora parpam may serves as a valuable lead for the clinical management of gastric ulcer.

Keywords: Anti-ulcer, Natural Poora parpam, Synthetic Poora parpam, Indomethacin, Gastric ulcer, Ulcer index, Histopathology.