Abstract

BIO-COORDINATION OF SCHIFF BASE DERIVED FROM AMOXICILLIN TRIHYDRATE AND PYRROLE-2-CARBALDEHYDE WITH Cu(II), Co(II) & Zn(II) IONS: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION

*N. K. Chaudhary

ABSTRACT

A new Schiff base ligand AMXPC was prepared by refluxing Amoxicillin trihydrate and Pyrrole-2-carbaldehyde in aqueous methanol solution in weak acidic medium. The metal complexes have been synthesized by using chloride salts of Copper, Cobalt and Zinc and they were characterized by analytical techniques viz: IR, 1H NMR, TOF mass and elemental analysis. The synthesized ligand along with their metal(II) complexes were screened for their in vitro antibacterial activity against three pathogenic bacteria E. coli, B. subtilis and S. aureus, by measuring diameter of zone of inhibition in mm. Amoxicillin trihydrate was taken as control drug. The result of these studies show the strong antibacterial activity of metal(II) complexes compared to ligand and control drug.

Keywords: Amoxicillin trihydrate, ?-lactam, amalgamation, Pyrrole-2-carbaldehyde, novel ligand.