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METHOD DEVELOPMENT AND DETERMINATION OF RISEDRONATE SODIUM IN PHARMACEUTICAL DOSAGE FORMS BY VISIBLE SPECTROPHOTOMETRY
P. V. Lakshmana Rao and C. Rambabu*
ABSTRACT Two simple, accurate and economic spectrophotometric methods A and B were developed for the determination of Risedronate sodium in bulk and dosage forms. These methods are based on the formation of chloroform soluble ion-associates in the presence of acidic dyes namely BPB (Method A) and BCP (Method B) exhibiting max at 420 and 416 nm respectively. These methods obey Beer’s law in the concentration range of 2.0-10.0 μg/ml and 2.0-10.0 μg/ml. The molar absorptivities are found to be 1.82x104 and 2.49x104 lt/mol.cm for methods A and B. These methods are found to be suitable for the assay of Risedronate sodium in pharmaceutical formulations. Keywords: Risedronate sodium, BPB, BCP, Spectrophotometry. [Download Article] [Download Certifiate] |