Abstract

THE ANTIMICROBIAL EFFECT OF SOME MEDICINAL PLANT, AND INTERACTIONS WITH NON-ANTIBIOTICS

Tarek El-Bashiti*, Mohamed M. Jouda and Atef Masad

ABSTRACT

The aim of the study was to assess the synergistic effect of some medicinal plant with non-antibiotic drugs against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. We used loperamid HCl, paracetamol and vitamin C as non-antibiotic drugs. The synergistic effect between plant extrcts and Non-antibiotic drugs was assessed using disk diffusion method. The results of this study showed that ethanolic extracts used against E. coli, S. aureus and P. aeruginosa showed antimicrobial and synergistic effect with most antibiotics better than methanolic and aquatic extracts. Water extracts were showed synergistic effect with the Paracetamol and Loperamide HCl better than methanolic and ethanolic extracts against E. coli and S.aureus. Ethanolic extracts showed synergistic effect with the Paracetamol and Loperamide Hcl better than methanolic and aquatic extracts against P. aeruginosa. Thereby, the results of this study were encouraging, despite the need for clinical studies to determine the real effectiveness and potential toxic effects in vivo. These results were revealed the importance of plant extracts when associated with antibiotic and Non-antibiotic drugs in control of bacteria.

Keywords: Plant extracts, Synergistic effects, Antimicrobial, Non-antibiotic drugs.