Abstract

MECHANISM OF ACTION OF RESVERATROL AND ANALOGUES FOR PREVENTION OF NEUROLOGICAL DISORDERS

Jonata Augusto de Oliveira and Mauricio Alexandre Reis Junior*

ABSTRACT

Several studies point to neuroinflammation as a contributing factor to the worsening of ischemia, Alzheimer's disease, Parkinson's disease, Huntington's disease and multiple sclerosis. Activation of microglia is considered as the first line of defense during neuroinflammation. After activation of microglia, occurs activation of several proinflammatory factors like as prostaglandins, cytokines, chemokines, complement proteins and reactive oxygen species. Numerous studies indicate that resveratrol acts like an activator of SIRT1. The activation of SIRT-1 protects neurons against inflammation and apoptosis. Furthermore, several assay have shown that resveratrol inhibit microglia activity and reduced signaling NF-kB, TNF-α and IL-1β. Through these studies, was concluded that resveratrol exerts neuroprotection by inhibiting activation of microglia, reducing the aggravation of ischemia, multiple sclerosis, Alzheimer's disease, Parkinson's disease and Huntington's disease. This revision extends our understanding about the mechanism of action of resveratrol and their analogues for prevention of neurological disorders.

Keywords: SIRT-1; Alzheimer's disease; Parkinson's disease; Resveratrol.