Abstract

CARDIOPROTECTION OF RESVERATROL AND ANALOGUES IN ISCHEMIA AND INFARCTION MYOCARDIAL

Jonata Augusto de Oliveira and Mauricio Alexandre Reis Junior*

ABSTRACT

Malignant ventricular arrhythmias and myocardial infarction it is one of main cause of death in the world with an estimated 17.3 million people annually. Cardiac arrhythmia is a disease associated with myocardial ischemia, which induces an imbalance between oxygen supply and metabolic demand in cardiac tissues. This imbalance causes functional alterations in the myocardium and may lead to cellular necrosis. Furthermore, it was shown in several studies that the formation of reactive oxygen species, in cardiovascular disease, increases the damage on cardiac tissue. Numerous studies have demonstrated that resveratrol acts the free radical scavenger by transferring the proton from its phenolic group to the free radicals reducing the formation reactive oxygen species and inhibiting NF-κB. Furthermore, has evidenced that resveratrol stimulates NO (nitricoxide), modulate vascular cell functions, increased activity of Ca2+-activated K+ (KCa) channels in vascular endothelial cells, alter eicosanoid metabolism, reduce lipoperoxidation, increase HDL and reducing cardiac apoptosis in ischemic-reperfused hearts. The objective of this review is extends our knowledge about the cardioprotective mechanisms of resveratrol and analogues in ischemia and infarction myocardial

Keywords: myocardial ischemia; antioxidant; infarction myocardial; resveratrol.