Abstract

MOLECULAR TARGETS OF RESVERATROL AND ANALOGUES AS ANTI-CANCER AGENT

Jonata Augusto de Oliveira and Mauricio Alexandre Reis Junior*

ABSTRACT

Cancer is most frequently diagnosed of diseases and main cause of deaths in worldwide. In 2008, has occurred 12.7 million of cancer diagnoses and 7.6 million of cancer deaths. Only on the United States, in 2014, occurred 1,665,540 new cases of cancer and 585,720 cancer related deaths. According to the statistical data, it is expected that the number of cancer-related deaths double in the next 50 years. Despite efforts enormous and countless studies, the treatment for cancer still remains a great challenge for the public health. In several in vitro studies it was demonstrated that resveratrol has antiinflammatory activity and anti-angiogenesis against cancer. However, the cancer displays deregulations of multiple signaling pathways, inhibition of apoptosis, uncontrolled cell proliferation, enhanced angiogenesis and enhanced uncontrolled migration of cells. The objective of this review is extends our knowledge about molecular targets of resveratrol for todevelop new drugs more potent and specific against cancer.

Keywords: cancer; angiogenesis; resveratrol; molecular targets.