Abstract

SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF SOME NEW MANNICH BASES

T.Thirugnanam*, D.Tamilvendan, G.Vishnuvardhanaraj, M.Amaladasan

ABSTRACT

The newly synthesized Mannich bases were characterized in this study on the basis of UV-Vis, FT-IR, FT-Raman, 1H NMR, 13C NMR, 2DNMR, Mass spectral techniques and elemental analysis. Antibacterial and antifungal study has been carried out for the Mannich bases against a panel of five Pathogenic bacterial strains namely, (Staphylococcus aureus, Klebsielloa Pneumonia, Bacillus anthracis, Escherichia coli, and, Bacillus cereus) and antifungal activity against a panel of five pathogenic fungal strains namely,(Aspergillus fumigates, Aspergillus nidulans , Aspergillus terreus , Aspergillus flavus , Aspergillus niger). Using gentamycin and tetracycline as standards. The synthesized compound contains significant antibacterial and antifungal activities.

Keywords: Mannich bases, formaldehyde, cinnmaldehyde derivatives, antibacterial activity, antifungal activity.