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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

SYNTHESIS OF PRODRUG OF ESTERS AND AMIDE LINKAGES OF NSAID HAVING CARBOXYLIC ACID, PHENOLIC AND IMINO GROUPS

Jalpa G. Patel and Prof. Dr. Dhrubo Jyoti Sen*

ABSTRACT

Ibuprofen, Diclofenac & Paracetamol have been taken as NSAID and three prodrugs have been synthesized by reacting of acid chloride of ibuprofen & diclofenac with paracetamol to get prodrug of ester linkage and acid chloride of ibuprofen has been reacted with diclofenac to get prodrug of amide linkage. These have been characterized by IR and authenticated by m.p. and logP values.

Keywords: Ibuprofen, Diclofenac sodium, Paracetamol, Thionyl chloride, Peptoid, logP, pKa, Melting Point, Prodrug.

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