Abstract

PHYSICOCHEMICAL PROPERTIES OF CIPROFLOXACIN IN AQUEOUS SOLVENT SYSTEMS AT DIFFERENT TEMPERATURES

G. S. Sanap*, S. B. Ingole, C. D. Thakur and A. G. Shankarwar

ABSTRACT

The study of the volumetric behavior of antibiotic Ciprofloxacin in solution provides information useful to elucidate ion–ion, ion–solvent, and solvent–solvent interactions. Apparent molar volumes (Φv), Partial molar volume (Φv0) and viscosity B-coefficients for Ciprofloxacin in aqueous system have been determined from density (ρ) and viscosity (η) measurements at four different temperatures using the ANTON PAAR densitometer and Mansing Survismeter respectively. Various concentrations of aqueous solutions of Ciprofloxacin ranging from 0.02 to 0.1 M were prepared. The apparent molar volumes were calculated from the density data. In addition, the concentration dependence of the apparent molar volumes was examined using Masson’s equation. The Jones-Dole equation was used to analyze viscosity data to obtain viscosity ‘A’ and ‘B’ coefficients. The concentration dependence of the apparent and partial molar volumes can be used to study ion–ion interactions, whereas the partial molar volumes at infinite dilution provide information on ion–solvent interactions.

Keywords: Ciprofloxacin, density, apparent molar volume, viscosity, B-coefficient.