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Abstract
DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF NOVEL QUINAZOLINE DERIVATIVES AS GSK-3? INHIBITORS
Srinivas S*, Aparna V.
ABSTRACT
A novel serial of 3-[2-(methyl amino) methyl]-5-{[(2-
phenylquinazolin-4-yl)oxy]methyl}-1,3,4-oxadiazole-2(3H)-thione and
N-4(substituted phenyl)-5-{[(2-phenylquinazolin-4-yl)-oxy]-methyl}-
1, 3, 4-thiadiazol-2-amine derivatives were synthesized, evaluated for
their hypoglycemic activity and molecular docking studies were
performed against X-ray crystal structure of GSK-3β, are shown their
role in the hypoglycemic activity. The molecules are the high potency
of compound 6a, 6g, 8a, 8b, and 8e based on glide score and binding
poses of the molecules.
Keywords:
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