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Abstract

DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF NOVEL QUINAZOLINE DERIVATIVES AS GSK-3? INHIBITORS

Srinivas S*, Aparna V.

ABSTRACT

A novel serial of 3-[2-(methyl amino) methyl]-5-{[(2- phenylquinazolin-4-yl)oxy]methyl}-1,3,4-oxadiazole-2(3H)-thione and N-4(substituted phenyl)-5-{[(2-phenylquinazolin-4-yl)-oxy]-methyl}- 1, 3, 4-thiadiazol-2-amine derivatives were synthesized, evaluated for their hypoglycemic activity and molecular docking studies were performed against X-ray crystal structure of GSK-3β, are shown their role in the hypoglycemic activity. The molecules are the high potency of compound 6a, 6g, 8a, 8b, and 8e based on glide score and binding poses of the molecules.

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