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SYNTHESIS, EVALUATION AND ANTIMICROBIAL ACTIVITY OF BENZOXAZOLE DERIVATIVES*Deepak Shrivastava Indore Institute of Pharmacy (IIP) Indore Rau-Pithampur Road Indore (M.P.) INDIA. ABSTRACT New 5methyl substituted phenol benzoxazoles derivatives were synthesized by the reaction of 5-methyl 2- amino phenol with various aldehydes in the presence of ethyl alcohol and lead tetra acetate. All the compounds were characterized by their analytical and spectral (IR, 1HNMR and Mass) data. Synthesized compounds have been evaluated for their antimicrobial (gram +ve and gram –ve) and antifungal activities (C. Albicans) by standard method at 50μg/ml and 100μg/ml concentration. Benzoxazole derivatives (DS-1 to DS-8) shown significant activity as compared to Griseofulvin standard drugs. Keywords: Antimicrobial activity, Antifungal activity, Benzoxazole. [Download Article] [Download Certifiate] |