Abstract

PHARMACOLOGICAL SIGNIFICANCE OF INHIBITORS OF METHYLTRANSFERASES-A REVIEW

S. Ghodgaonkar*, S. Bhandari and P. Shinde

ABSTRACT

DNA methylation is of great import in eukaryotes, and is one of the important processes in tumor formation further leading to neoplasm. S-adenosine-L-methionine dependent methyltransferases (AdoMet) are involved in the biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing. It plays an important role in development of tumor. These enzymes also play a pivotal role in treatment of many diseases ranging from cancer to diabetes to anti-oxidant activity. This review illustrates the current status of pharmacological significance of inhibition methyl transferases. It also provides a rationale for continued development of methyl transferase inhibitors.

Keywords: Methyltranferase, Methyl Tranferase Inhibitors, Cancer.