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AGE-RELATED CHANGES IN THE PHARMACOKINETICS OF FLORFENICOL AFTER INTRAMUSCULAR ADMINISTRATION IN SHEEP AND GOAT
*Mohamed El-Hewaity and Hanem El-Gendy
ABSTRACT
The comparative pharmacokinetic profile of florfenicol was studied in one-month and one-year old sheep and goat following intramuscular injection of 20 mg/kg body weight. Florfenicol concentrations in serum were controlled by microbiological test method utilizing Bacillus subtilis (ATCC 6633) as test organism. Following intramuscular administration of florfenicol in one-month and one-year old sheep and goat, serum concentration-time data were adequately described by a two-compartment open model. The absorption half-lives were 0.259, 0.361, 0.306 and 0.322 h, respectively. The maximum serum concentrations were significantly increased in one-year old sheep and goat compared to one-month old sheep and goat. The elimination half-life and MRT values of florfenicol were longer in one-month old sheep Keywords: Age-related pharmacokinetics florfenicol intramuscular sheep and goat. [Download Article] [Download Certifiate] |