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Abstract

COMPARATIVE STUDY OF COMMERCIALLY AVAILABLE BRANDS OF ACETAMINOPHEN IN LAHORE, PAKISTAN

Muhammad Asim Farooq*, Daulat Haleem Khan, Umair Ikram Dar, Izzatullah Khan, Rai Waqas1, Saad Tanvir, Anum Farooq and Muhammad Sohail

ABSTRACT

Acetaminophen is a non-steroidal anti-inflammatory drug frequently prescribed for relief of pain and fever. The present study was conducted to access the quality control parameters of 3 different brands available in current pharmaceutical market of Lahore, Pakistan. The purpose of current study to performed various quality control tests like weight variation, hardness, friability, disintegration, dissolution prescribed in official monograph. The results of 3 brands were meet prescribed official monograph. All the brands disintegrate within 15 minute prescribed in official monograph. The percentage of active ingredients was acceptable range mentioned in monographs. Drug regulatory authority needs to ensure the continuity of quality control parameters of acetaminophen to manufacturer.

Keywords: Acetaminophen, UV spectrophotometer, FTIR, Hardness, Quality control parameter.


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