Abstract

LIPID PROFILE, UREA, AND URIC ACID SERUM LEVELS IN SUBJECTS WITH DIABETES AND\OR PERIODONTITIS COMPARED TO CONTROLS.

Abdulsalam Tawfeeq Salih Alsamarai*, Amina Hamed Ahmed, Wesam Suhail Najem, Abdulghani Mohamed Alsamarai

ABSTRACT

Background: Diabetes mellitus and periodontitis are two conditions that characterized with metabolic, inflammatory and immunologic changes that may lead to serious complications, including infection and cardiovascular diseases. Aim: To determine the predictive value of lipid profile, glucose, urea and uric acid in these two conditions alone or in combination in comparison with control. Study Design: Prospective case control study. Materials and Methods: A total of 226 subjects recruited from Endocrinology Unit, Samara General Hospital during the period from 1st October 2014 to end of October 2015. Their age ranged from 32 to 75 years. The study population depending on their clinical and laboratory findings divided in to non- diabetic without periodontitis as control, diabetic, periodontitis without diabetes, and diabetic with periodontitis groups. Blood samples collected from subjects and serum isolated and tested for lipid profile, blood urea and sugar, and serum uric acid using enzymatic methods. Results: All tested markers with the exception of HDL were significantly higher in diabetic group and those with periodontitis and diabetic than in control, while HDL was significantly lower in both groups than in control. There was no significant differences in all markers between periodontitis and control groups; in between periodontitis with diabetic and diabetic group. However, there was significant higher value in those with diabetes and periodontitis as compared to subjects with periodontics. HDL was inversely correlated to cholesterol, triglyceride and LDL in control group, while this pattern of correlation not demonstrated in the 3 patients groups, indicating abnormal metabolic changes. Conclusion: Both diabetes and periodontitis as present alone or in combination were associated with lipid profile, blood urea, and uric acid disturbances. This finding clarify the importance of monitoring both conditions for the achievement of good prognosis and prevent complications.

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